Clinical Immunology
by Robert R. Rich, Thomas A. Fleisher, Harry W. Schroeder Jr., Cornelia M. Weyand, David B. Corry, Jennifer M. Puck
Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume.Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine.Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma.Provides new genetics content focused on data applications.Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more.Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics.Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.Summarizes promising research and development anticipated over the next 5-10 years with "On the Horizon" boxes and discussions of translational research.An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Hardcover
English
Brand New
Table of Contents
PART I Principles of Immune Response1 The Human Immune Response2 Organization of the Immune System3 Innate Immunity4 Antigen Receptor Genes, Gene Products, and Co-Receptors5 The Major Histocompatibility Complex6 Antigens and Antigen Presentation7 B-Cell Development and Differentiation8 Immunoglobulin Function9 T-Cell Development10 T-Cell Activation and Tolerance11 Helper T-Cell Subsets and Control of the Inflammatory Response12 Cytotoxic T Lymphocytes and Natural Killer Cells13 Regulatory Immune Cells14 Cytokines and Cytokine Receptors15 Chemokines and Chemokine Receptors16 Lymphocyte Adhesion and Trafficking17 Death Pathways and ImmunogenicityPART II Fundamentals of Host-Environmental Interactions18 Human Genomics in Immunology19 Regulatory RNA in Immunologic Diseases20 Immunometabolism21 Immune Deficiencies at the Extremes of Age22 The Microbiota in Immunity and InflammationPART III Host Defenses to Infectious Agents23 Immunology of the Skin24 Immunology of Mucosal Surfaces25 Host Defenses to Viruses26 Host Defenses to Intracellular Bacteria27 Host Defenses to Extracellular Bacteria, Including Spirochetes28 Host Defenses to Fungi29 Host Defenses to Protozoa30 Host Defenses to Helminth Infection31 Emerging Pandemic Infectious Disease ThreatsPART IV Immune Deficiency and Immune Regulatory Disorders32 Approach to the Evaluation of the Patient With Suspected Immunodeficiency33 Primary Antibody Deficiencies34 Primary T-Cell Immunodeficiencies35 Genetic Disorders of Interferons-, Interleukin-17, Interleukin-18, and Nuclear Factor-?B-Mediated Immunity36 Hemophagocytic Lymphohistiocytosis37 Autoinflammatory Syndromes38 Immune Regulatory Disorders39 Neutrophils and Neutrophil Disorders40 Complement and Complement Disorders41 Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome42 Autoantibody-Mediated Phenocopies of Primary Immunodeficiency DiseasesPART V Allergic Diseases43 Allergic Airway Diseases44 Mast Cells and Mast Cell Disorders45 Eosinophils and Eosinophilic Disorders46 Urticaria, Angioedema, and Anaphylaxis47 Allergic Reactions to Stinging and Biting Insects48 Atopic and Contact Dermatitis49 Food Allergy50 Drug HypersensitivityPART VI Systemic Immune Diseases51 Mechanisms of Autoimmunity52 Systemic Lupus Erythematosus53 Rheumatoid Arthritis54 Juvenile Idiopathic Arthritis55 Sjögren's Syndrome56 Scleroderma-Systemic Sclerosis57 Inflammatory Muscle Diseases58 Spondyloarthritis59 Small- and Medium-Vessel Primary Vasculitis60 Large Vessel Vasculitides61 Antiphospholipid SyndromePART VII Organ-Specific Inflammatory Disease62 Immunohematologic Disorders63 Bullous Diseases of the Skin and Mucous Membranes64 Immunology of Psoriasis65 Myasthenia Gravis66 Multiple Sclerosis67 Autoimmune Peripheral Neuropathies68 Immunologic Renal Diseases69 Immunologic Mechanisms of Atherosclerosis and Myocarditis70 Autoimmune Thyroid Diseases71 Type 1 Diabetes72 Immunologic Lung Diseases, 91973 Chronic Obstructive Pulmonary Disease and Emphysema74 Immunologic Ocular Disease75 Immunologic Diseases of the Gastrointestinal Tract76 Inflammatory Hepatobiliary DiseasesPART VIII Immunology and Immunotherapy of Neoplasia77 Lymphoid Leukemias78 Lymphomas79 Monoclonal Gammopathies80 Immune Responses to Solid Tumors and Immune Checkpoint Therapy81 CAR T-Cell TherapyPART IX Medical Management of Immunological Diseases82 Immunoglobulin Therapy: Replacement and Immunomodulation83 Glucocorticoids84 Immunomodulating Drugs85 Protein Kinase Antagonists86 Biologic Response Modifiers87 Vaccines88 Allergen Immunotherapy for Allergic DiseasesPART X Transplantation89 Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance90 Allogeneic Transplantation for Immunodeficiency91 Gene Therapy for Primary Immune Deficiency Diseases92 Hematopoietic Stem Cell Transplantation for Malignant DiseasesPART XI Diagnostic Immunology93 Flow Cytometry94 Assessment of Functional Immune Responses in Lymphocytes95 Assessment of Neutrophil Function96 Assessment of Human Allergic DiseasesAppendix 1: Selected CD Molecules and Their CharacteristicsAppendix 2: Laboratory Reference ValuesIndex
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