Published with the New York Academy of Sciences A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the world. Written for researchers and clinicians alike, the book features edited contributions from distinguished experts in the field, taking a focused, yet wide-ranging approach to the subject. It begins by exploring the pathways and networks mediating migraine headaches, their underlying physiological mechanisms, characteristics of visceral pain, and the concept of dural neurogenic inflammation. From there the authors delve into the mechanisms sustaining the head pain and photophobia associated with migraines, and they review the pharmacology of newly discovered migraine treatments. These basic chapters are followed by clinical and genetic studies linking to key issues, including cortical spreading depression, ion channels, transporters, and epilepsy. * Reviews of the latest advances in our understanding of the neurobiological basis of migraine * Translates important research findings from around the globe into novel treatments strategies currently being investigated * Provides researchers and clinicians with a deep understanding of the primary mechanisms of migraine from migraine modeling to clinical applications * Includes contributions by many of the most respected researchers in the field, world-wide * Discusses exciting recent developments in migraine mutations and their role in CSD, as well as the role of CSD in aura and trigeminal activation Timely, comprehensive, and authoritative, Neurobiological Basis of Migraine is an indispensable working resource for clinicians and migraine, headache, and pain researchers, including neurobiologists, neuropharmacologists, neurologists, and vascular neurobiologists, as well as graduate students in those fields who are involved in researching migraine headaches.

About the Editors Turgay Dalkara, MD, PhD is Professor Neurology and Chair of the Institute of Neurological Sciences and Psychiatry at Hacettepe University, Ankara, Turkey. He also holds a joint appointment at the department of Radiology at the Massachusetts General Hospital, Harvard University, Boston. Michael A. Moskowitz, MD is Professor of Neurology at Harvard Medical School and a former Member of the Harvard-MIT Division of Health Science & Technology. He is also a senior neuroscientist in the Departments of Radiology and Neurology at the Massachusetts General Hospital, Boston.

Foreword Hans-Christoph Diener Anatomy and physiology 1) Functional anatomy of trigeminaovascular pain Messlinger and Dux 2) Physiology of the meningeal sensory pathway Strassman and Melo-Carrillo 3) Meningeal afferent ion channels and their role in migraine Dussor 4) Functional Architecture of Central Pain Pathways: Focus on the Trigeminovascular System Noseda and Villanueva Special features of migraine pain 5) Visceral Pain Gold and Gebhart 6) Meningeal Neurogenic Inflammation and Dural Mast Cells in Migraine Pain Levy 7) Sensitization and photophobia in migraine Schain and Burstein 8) Central circuits promoting chronification of migraine Atcherley, Nation, Felice, Xie, Ossipov, Dodick and Porreca 9) Triptans to Calcitonin gene-related peptide modulators - small molecules to antibodies - the evolution of a new migraine drug class Hargreaves 10) Lessons learned from CGRP mutant mice Sowers, Tye and Russo Clinical Characteristics of Migraine 11) The Clinical Characteristics of Migraine Cutrer, Smith and Dodick 12) The Premonitory Phase of Migraine Viana and Goadsby Migraine genetics and CSD 13) The Genetic Borderland of Migraine and Epilepsy Aiba and Noebels 14) Genetics of monogenic and complex migraine Tolner, Eising, Terwindt, Ferrari and Maagdenberg 15) Lessons from familial hemiplegic migraine and cortical spreading depression Daniella Pietrobon 16) From cortical spreading depression to trigeminovascular activation in migraine Dalkara and Moskowitz Modeling and imaging in migraine 17) Mathematical modeling of human cortical spreading depression Dahlem 18) Tools for high resolution in vivo imaging of cellular and molecular mechanisms in cortical spreading depression and spreading depolarization K1l1ç, Uhlirova, Tian, Saisan, Yaseen, Lee,. Vinogradov, Boas, Sakad?ic and Devor 19) Animal models of migraine aura Chen, Theriot, Ayata and Brennan 20) Human models of migraine Hansen and Ashina 21) Imaging pain and headache Hodkinson Wilcox and Borsook