How to weigh genetic factors while choosing the best psychosocial interventions Psychosocial Interventions for Genetically Influenced Problems in Childhood and Adolescence explores empirically supported psychosocial interventions in light of our current understanding of the genome. It considers how interventions may be modified and enhanced as the products of genomic research continue to expand - and why they offer the most promise for making substantial gains in treatment and prevention. Providing a clear, accessible assessment of our current knowledge, both of the genome and evidence based treatments, Psychosocial Interventions for Genetically Influenced Problems in Childhood and Adolescence provides practical advice to clinicians,policy makers, and others invested in treating young people who present with a variety of conditions including anxiety, depression, ADHD, autism, substance abuse, and dyslexia. Rende discusses the current understanding of genetic etiology of psychopathology, and explores the support, or lack thereof, for various modes of treatment in light of new genomic knowledge. The overall premise is that our advances in genetics will be put to best therapeutic use by fueling translational psychosocial interventions. Key points raised include: * The need for treating children suffering today, rather than waiting for a biological "magic bullet" * Discussion of how empirically-supported interventions mesh with genetic vulnerabilities * Ways in which interventions may change as genetic research continues

Richard Rende, Ph.D., is a nationally and internationally recognized researcher who combines expertise at the intersection of developmental psychopathology and developmental behavioral genetics. As Associate Professor of Psychiatry and Human Behavior at Alpert Medical School of Brown University, he has been awarded multiple grants from 4 branches of the National Institutes of Health. He is the founder of Social Behavioral Research Applications (SBRA), a unique consultation service for industry, government, and academics. Rende developed the Red-Hot Parenting blog for and a monthly column for the New Bedford Standard Times. His work has been featured on NPR, ABC News, The Huffington Post, Yahoo!, , , and MSNBC.

Chapter 1 Prelude: Great Expectations AREN'T MAGIC BULLETS POSSIBLE? SO AREN'T SIMILAR SUCCESS IMMINENT? WHAT WILL BE THE YIELD OF GENETIC RESEARCH IN TERMS OF INTERVENTION? WHERE WILL ALL OF THIS LEAD? Chapter 2 Autism Spectrum Disorder: Can We Use Environmental Intervention To Reprogram Genetic Effects? GENOMIC APPROACHES TO ASD IS THERE A NEW FUNDAMENTAL ETIOLOGICAL MODEL OF ASD? GENOMICS, COMPLEX DISORDERS, HYPE, AND HOPE USING THE ENVIRONMENT TO REPROGRAM THE EFFECTS OF GENES SO WHAT'S NEXT? REFERENCES Chapter 3 Attention-Deficit Hyperactivity Disorder And Reading Disorder: Illuminating How The Environment Shapes Highly Heritable Disorders GENETIC MODELS OF ADHD AND RD: WHY HAS GENE DISCOVERY BEEN SO ELUSIVE? WHY WOULD THE ENVIRONMENT BE IMPORTANT FOR HIGHLY HERITABLE DISORDERS? MORE NUANCED MODELS OF GENE-ENVIRONMENT INTERPLAY FOR ADHD AND RD THE PROMISE OF PSYCHOSOCIAL INTERVENTIONS CONCLUDING REMARKS REFERENCES Chapter 4 Conduct Problems and Substance Use: The Underappreciated Role Of Shared Environmental Influences GENETIC MODELS OF CP AND SU THE IMPACT OF SHARED ENVIRONMENTAL INFLUENCES GETTING MOLECULAR ABOUT THE ENVIRONMENT A DEVELOPMENTAL GENE-ENVIRONMENT MODEL FAMILY-BASED INTERVENTIONS AND GENETIC EPIDEMIOLOGY SUMMARY AND LOOKING AHEAD REFERENCES Chapter 5 Depression: The Importance Of The Family As A Context For Gene Expression HIGH-RISK STUDIES OF OFFSPRING OF DEPRESSED PARENTS GENETIC MODELS OF MDD GxE INTERACTION AND DEPRESSION DEPRESSION IN ADOLESCENTS AND CHILDREN WHO SHOULD BE TREATED IN FAMILIES AT RISK? IMPLICATIONS OF THE PARENTAL TREATMENT STUDIES Selected Readings Chapter 6 Pediatric Bipolar Disorder: Complex Phenotypes, Genotypes, And Environments CURRENT THINKING ON THE GENETICS OF BP IS PBD AN EARLY MANIFESTATION OF GENETIC RISK TO BP? THE CLINICAL COMPLEXITY OF PBD EMPHASIZING PSYCHOSOCIAL INTERVENTIONS FOR PBD CONCLUSIONS SELECTED READINGS Chapter 7 Pediatric Anxiety Disorders: The Intersection Of Genes And Environments THE HETEROGENEITY OF ANXIETY DISORDERS: FOCUSING ON ANXIETY-RELATED BEHAVIORS IN CHILDHOOD AND ADOLESCENCE ANXIETY IN THE FAMILY: THE INTERSECTION OF GENES AND PARENTING GENES, ENVIRONMENT, AND ANXIETY: NEWER METHDOLOGIES CONCLUDING REMARKS SELECTED READINGS Chapter 8 The Future: Why Psychosocial Intervention Will Matter Even More FUTURE GENETIC RESEARCH AND THE CONCEPTUALIZATION OF DISORDERS GENOMICS MAY REFINE DIAGNOSIS AND POINT TO TAILORED INTERVENTIONS GENOMICS WILL LEAD TO EARLIER INTERVENTION GENOMICS WILL ACCELERATE THE DEVELOPMENT OF PSYCHOSOCIAL INTERVENTIONS BUT WILL WE DISCOVER MAGIC BULLETS?