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The revised guide to the diagnosis, management, and treatment of blood disorders and cancer in children Children with blood disorders and cancer are a unique population that require specialized diagnostic considerations and management. The Handbook of Pediatric Hematology and Oncology has been designed to provide clinicians of all levels with practical guidance through an up-to-date algorithmic approach to these conditions. Assembled by a team of experts from the world-class Children's Hospital & Research Center Oakland, this updated third edition: Presents up-to-date management and treatment guidelines for the most common pediatric blood disorders and malignancies Provides an updated algorithmic approach for the diagnosis and management of the most common conditions and suggested readings Utilizes rapid-referral tables containing visual representations of symptoms, lab findings, differentials, and treatment guidance Incorporates case studies covering different hematologic and oncologic conditions, such as hemolytic anemia, sickle cell disease, hemophilia, neuroblastoma, and sarcomas of the soft tissue and bone Includes a useful formulary that lists chemotherapy agents, dosing, mechanism of action, pregnancy category, indications, and side effects Covers transfusion medicine, stem cell transplantation, management of central venous catheters, acute pain management, oncologic emergencies, and chemotherapy basics With its direct guidance and portable design, the Handbook of Pediatric Hematology and Oncology: Children's Hospital & Research Center Oakland, Third Edition, will prove an invaluable resource to medical students, residents, pediatric hematology and oncology nurses, pediatricians, and early-career providers in pediatric hematology and oncology.

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The revised guide to the diagnosis, management, and treatment of blood disorders and cancer in children Children with blood disorders and cancer are a unique population that require specialized diagnostic considerations and management. The Handbook of Pediatric Hematology and Oncology has been designed to provide clinicians of all levels with practical guidance through an up-to-date algorithmic approach to these conditions. Assembled by a team of experts from the world-class Children's Hospital & Research Center Oakland, this updated third edition: Presents up-to-date management and treatment guidelines for the most common pediatric blood disorders and malignancies Provides an updated algorithmic approach for the diagnosis and management of the most common conditions and suggested readings Utilizes rapid-referral tables containing visual representations of symptoms, lab findings, differentials, and treatment guidance Incorporates case studies covering different hematologic and oncologic conditions, such as hemolytic anemia, sickle cell disease, hemophilia, neuroblastoma, and sarcomas of the soft tissue and bone Includes a useful formulary that lists chemotherapy agents, dosing, mechanism of action, pregnancy category, indications, and side effects Covers transfusion medicine, stem cell transplantation, management of central venous catheters, acute pain management, oncologic emergencies, and chemotherapy basics With its direct guidance and portable design, the Handbook of Pediatric Hematology and Oncology: Children's Hospital & Research Center Oakland, Third Edition, will prove an invaluable resource to medical students, residents, pediatric hematology and oncology nurses, pediatricians, and early-career providers in pediatric hematology and oncology.

Author Biography

Caroline A. Hastings, MD, Department of Hematology and Oncology, Children's Hospital & Research Center at Oakland, Oakland, CA, USA. Joseph C. Torkildson, MD, MBA, Department of Hematology and Oncology, Children's Hospital & Research Center at Oakland, Oakland, CA, USA. Anurag K. Agrawal, MD, Department of Hematology and Oncology, Children's Hospital & Research Center at Oakland, Oakland, CA, USA.

Table of Contents

Preface ix Acknowledgments xi 1 Approach to the Anemic Child 1 2 Hemolytic Anemia 15 3 Sickle Cell Disease 27 4 Thalassemia 51 5 Transfusion Medicine 63 6 Chelation Therapy 79 7 Approach to the Bleeding Child 85 8 Von Willebrand Disease 95 9 Hemophilia 103 10 Thrombophilia 111 11 The Neutropenic Child 119 12 Thrombocytopenia 133 13 Evaluation of the Child with a Suspected Malignancy 157 14 Oncologic Emergencies 173 15 Acute Leukemias 191 16 Central Nervous System Tumors 211 17 Hodgkin and NonHodgkin Lymphoma 227 18 Wilms Tumor 239 19 Neuroblastoma 245 20 Sarcomas of the Soft Tissues and Bone 253 21 Germ Cell Tumors 265 22 Rare Tumors of Childhood 275 23 Histiocytic Disorders 287 24 Hematopoietic Stem Cell Transplantation 295 25 Supportive Care of the Child with Cancer 313 26 Central Venous Catheters 323 27 Management of Fever in the Child with Cancer 333 28 Acute Pain Management in the Inpatient Setting 347 29 Palliative Care 361 30 Chemotherapy Basics 377 31 Guide to Procedures 393 32 Treatment of Chemotherapy Extravasations 403 Formulary 409 Index 489

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