*Amazing Spider-Man #300*, published in May 1988, is a landmark issue notable for the first full appearance of Venom. The story involves Spider-Man, now back in his red and blue costume, facing Venom, who emerges from the fusion of Eddie Brock and the alien symbiote. This issue was scripted by David Michelinie, with Todd McFarlane handling the pencils and inks. It marks a significant moment in Spider-Man's history, celebrating Spider-Man's 25th Anniversary while introducing one of his most iconic adversaries.