Publisher Description

This book is a state-of-the-art reference work covering every aspect of the field of renal cell cancer, from diagnostics to clinical management. It provides an overview of new information concerning epidemiology, molecular and immunologic characteristics, as well as surgical therapy. Particular focus is given to the latest diagnostic tests and genetic counseling. Associated topics such as pain management and palliative care are also covered. It is a vital reference tool for urologists, oncologists and radiologists alike, being the most comprehensive volume available on the subject.

Notes

This book is a state-of-the-art reference work covering every aspect of the field of renal cell cancer. It is quite simply the most comprehensive volume available on the subject, dealing as it does with topics ranging from diagnostics to clinical management. It provides an overview of new information concerning epidemiology, molecular and immunologic characteristics, as well as surgical therapy. Particular focus is given to the latest diagnostic tests and genetic counseling. Associated topics such as pain management and palliative care are also covered. A significant section is given over to immuno- and chemotherapy and upcoming developments in the field. In all, it is a vital reference tool for urologists, oncologists and radiologists alike, being the most comprehensive volume available on the subject.

Back Cover

Renal Cell Cancer: Diagnosis and Therapy covers diagnostics, cancer research, molecular biology, immunology and clinical management. It provides an overview of new information in epidemiology, molecular and immunologic characteristics, and surgical therapy. The state-of-the-art reference work covering renal cell cancer in its full extent currently on the market, it presents every aspect on the topic, new data and techniques, with a special focus on the latest diagnostic tests, genetic counselling, surgery - including laparoscopy and minimally invasive therapies. Special topics are included, such as advanced disease, special situations, pain management, palliative care and follow-up. A significant part of the book deals with immunotherapy and the exciting new developments in molecular targeted therapy, including angiogenesis inhibitors, tyrosine kinase inhibitors and mTOR inhibitors, for patients with advanced renal cell carcinoma. Renal Cell Cancer: Diagnosis and Therapy is the reference work of choice on this topic for urologists and oncologists.

Table of Contents

Epidemiology of Renal Cell Carcinoma.- Natural History of Renal Cell Carcinoma.- Pathology of Renal Cell Carcinoma: Correlation of Morphology, Immunophenotype, and Genetic and Clinical Aspects.- Staging of Renal Cell Carcinoma.- Prognostic Factors: Markers.- Diagnostic Tests.- Ultrasound in Diagnosis and Follow-Up of Renal Cell Cancer.- Computer Tomography in Renal Cell Cancer.- Magnetic Resonance Imaging of Renal Cell Cancer.- Angiography as a Diagnostic Tool in Renal Cell Carcinoma.- Positron Emission Tomography in Renal Cancer.- Biopsies and Cytological Punctures.- Hereditary Factors.- von Hippel–Lindau Disease.- Genetic Counseling for Inherited Forms of Kidney Cancer.- Surgery.- Open Radical Nephrectomy for Localized Renal Cell Carcinoma.- Radical Nephrectomy, Laparoscopic Transperitoneal.- Retroperitoneoscopic Radical Nephrectomy.- Radical Nephrectomy: Lymph Node Dissection.- Nephron-Sparing Surgery: Partial Nephrectomy Open.- Nephron-Sparing Surgery: Laparoscopic Partial Nephrectomy.- How Much Margin to Spare in Partial Nephrectomy.- Advanced Tumors: Tumor Thrombus.- Complicated Tumors: Bench Surgery.- Advanced Disease: Nonpulmonary Metastases.- Local Recurrence After Radical Nephrectomy for Renal Cell Carcinoma.- Minimal Invasive Therapies.- Cryosurgery.- Radiofrequency Ablation of Renal Masses.- High-Intensity Focused Ultrasound.- Current Status of Photodynamic Therapy for Renal Tumors.- Complicated Cysts and Cystic Carcinomas.- Nephron-Sparing Surgery for Central Renal Tumors.- Bilateral Renal Masses.- Old and Fragile Patients.- Obesity and Coumadin in Kidney Cancer.- Obesity and Kidney Cancer.- Coumadin and Kidney Cancer.- Embolization.- Benign Tumors of the Kidney.- Bone Metastases.- Radiotherapy.- Surgery.- Medical Management.- Immunotherapy.-Antiangiogenic Therapies in Renal Cell Carcinoma.- Signal Transduction Inhibitors in Renal Cell Cancer.- Cytotoxic Chemotherapy for Metastatic Renal Cell Cancer.- Cell-Based Vaccines for Renal Cell Carcinoma.- Monoclonal Antibody-Based Therapy.- Hematopoietic Stem Cell Transplantation: Allogeneic Immunotherapy for Cancer.- Bisphosphonate Treatment for Osteolytic Bone Metastases Associated with Renal Cell Carcinoma.- Therapeutic Counseling for the Medical Management of Renal Cell Carcinoma.- Trends in Medical Management of Renal Cell Cancer.- Models of Human Renal Cell Carcinoma.- Follow-Up Strategies for Renal Cell Carcinoma After Nephrectomy.- Palliative Treatment in Renal Cell Cancer.- Future Directions.

Review

From the reviews:"Renal-Cell Carcinoma, a Malignant Tumor that is associated with a poor prognosis, is difficult to diagnose in its early stages and difficult to treat successfully. This book provides an overview of the epidemiology, diagnosis, and management of this type of tumor. … They aim the book primarily at urologists and urologic oncologists … . The accompanying radiographic figures vividly clarify the role that medical imaging plays in diagnosis and staging." (Robert J. Motzer, The New England Journal of Medicine, Vol. 360 (18), April, 2009)

Long Description

Althoughthefirstnephrectomywasperformedasearlyas1867bySpillgeberg,itwas notuntil1903thatGregoireperformedthefirstformalnephrectomy. Itwas,however, sixdecadeslaterthatRobsonpublishedhisradicalnephrectomyseries. Sincethenradical nephrectomyhasbecomethecornerstoneofthesurgicaltreatmentofrenalcellcarcinoma. Duringthepastdecade,urologyhasbeenfacingrapidchangesintheunderstanding of oncological urology. Changes in surgical treatment strategies accompanied by the availabilityofnewereffectivemedicaltherapieshaveledtoimprovedresults. Inaddition, laparoscopicradicalnephrectomyhasbecomethestandardofcareforthetreatmentof localizedrenalcellcancer. The expanded use of imaging techniques has resulted in detection of an increasing numberofsmallrenalcellcancers. Forthemajorityofthesetumors,radicalnephrectomy isconsideredovertreatment,andnephronsparingsurgeriessuchaspartiallaparoscopic nephrectomy or tumor ablative surgery, using various different energy sources, has becomeroutine. Themedicalmanagementofrenalcellcarcinomahasrecentlyexperiencedanexciting revolution with approvals of new pharmaceuticals in a disease that was previously consideredrefractorytomosttherapies. Increasingunderstandingofthemolecularbiology of kidney cancer has led to this remarkable progress. Several biologic agents aiming at angiogenesis, growth factors and their pathways have produced extremely dramatic results. Inaddition,newersophisticatedradiologicalmethodsareincreasinglybeingused toevaluatetumorbloodflowandresponsetotherapy. Inadditiontobettertreatmentsthistextbookalsoexploresuponimproving,making a proper precocious diagnosis and optimizing follow-up. To accomplish this, specific markersneedtobedevelopedandimagingmodalitiesshouldbeimproved. Thistextbookaimsatcoveringtheentirefieldofthecurrentknowledgeofrenalcell cancer, presented by some of the finest experts in the field. In addition to reflecting uponpastandpresentachievements,thisworkalsoaimsataddressingpossiblefuture developmentsinthisfield. JeanJ. M. C. H. delaRosette CoraN. Sternberg HeinP. A. vanPoppel v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1 EpidemiologyofRenalCellCarcinoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 IntanP. E. D. K

Review Quote

From the reviews:"Renal-Cell Carcinoma, a Malignant Tumor that is associated with a poor prognosis, is difficult to diagnose in its early stages and difficult to treat successfully. This book provides an overview of the epidemiology, diagnosis, and management of this type of tumor. … They aim the book primarily at urologists and urologic oncologists … . The accompanying radiographic figures vividly clarify the role that medical imaging plays in diagnosis and staging." (Robert J. Motzer, The New England Journal of Medicine, Vol. 360 (18), April, 2009)

Feature

First comprehensive and THE most contemporary book on renal cell carcinoma Only book to focus on different topics in the field of renal cell cancer ranging from diagnostics, cancer research, molecular biology, immunology and clinical management Presents the current status of different surgical options in one book: an overview of radical nefrectomy - partial nefrectomy - laparoscopic renal surgery - minimally invasive surgery

Description for Sales People

This book is a state-of-the-art reference work covering every aspect of the field of renal cell cancer. It is quite simply the most comprehensive volume available on the subject, dealing as it does with topics ranging from diagnostics to clinical management. It provides an overview of new information concerning epidemiology, molecular and immunologic characteristics, as well as surgical therapy. Particular focus is given to the latest diagnostic tests and genetic counseling. Associated topics such as pain management and palliative care are also covered. A significant section is given over to immuno- and chemotherapy and upcoming developments in the field. In all, it is a vital reference tool for urologists, oncologists and radiologists alike, being the most comprehensive volume available on the subject.

Details